What if Gwen Stacy were bitten by the radioactive spider, not Peter Parker? Find out on Earth-65! There, Gwen is the spectacularly misunderstood Spider-Woman - and she's wanted for Peter's death! And that's bad news, especially since Gwen's dad is a cop! When a Lizard-like menace runs amok, it brings back painful memories for Gwen - but will Captain America's mighty shield inflict new ones? Web-slinging doesn't leave much time for Gwen to play drums with her band, the Mary Janes - but on Halloween, they'll share a night to remember, courtesy of Mysterio! Then, switch genres from horror to romance when Miles "Spider-Man" Morales swings by for an interdimensional team-up! Plus, fl ash back to an early Spider-Gwen encounter...with She-Hulk?!